Effect of ethanol extract Sonchus arvensis Linn. Jamu formula could reduce plasma cholesterol patients with mild hypercholesterolemia. Pengaruh jamu obesitas terhadap indeks massa tubuh, lingkar perut, dan lingkar lengan dibandingkan dengan orlistat dan evaluasi keamanannya. p 18–9.Īrdiyanto D, Triyono A, Novianto F, Mana AT. Manila: World Health Organization Regional Office of Western Pacific 1993. Research guidelines for evaluating the safety and efficacy of herbal medicines. Jamu, obat tradisional asli Indonesia: pasang surut pemanfaatannya di Indonesia. Jakarta: Badan Pengawas Obat dan Makanan 2019. Peraturan Badan Pengawas Obat dan Makanan Nomor 32 Tahun 2019 tentang Persyaratan Keamanan dan Mutu Obat Tradisional.
Jakarta: Menteri Koordinator Bidang Pembangunan Manusia dan Kebudayaan Republik Indonesia 2019. Keputusan Menteri Koordinator Bidang Pembangunan Manusia dan Kebudayaan Republik Indonesia Nomor 22 Tahun 2019 tentang Satuan Tugas Percepatan Pengembangan dan Pemanfaatan Fitofarmaka. Journal of Clinical Research & Bioethics. Safety, efficacy, regulations and bioethics in herbal medicines research and practice. Journal of Pharmacy and Bioallied Sciences. Challenges and guidelines for clinical trial of herbal drugs.
Parveen A, Parveen B, Parveen R, Ahmad S. WHO global report on traditional and complementary medicine 2019. The cholesterol-lowering herbal medicine does not change the function of the liver, kidneys and blood, with mild side effects of increasing the frequencies of bowel movements and stomachaches. The paired t test analysis showed no differences in average laboratory parameters on day (D)-14 and D-28 compared to the baseline (p > 0.05). These effects were still in a normal range and can be tolerated by the subjects. The results showed increasing in bowel frequencies of 92% subjects and abdominal pain in bowel movements of 34% subjects. The data were analyzed descriptively and statistically using SPSS. Subjects were requested to boil the herb everyday and drank it twice a day. Outcome parameters included clinical signs and symptoms, liver function laboratory tests (SGOT, SGPT), renal function (ureum, creatinine) and routine blood counts (hemoglobin, leukocyte, platelets, hematocrit).
The intervention was conducted for 28 days at the Hortus Medicus Herbal Medicine Research House (RRJ) in 2014. This study is a phase one of clinical trial with a pre-post group design, a single arm, involving 50 subjects with mild hypercholesterolemia without any complications and comorbidities. This study aimed to determine the safety of the cholesterol-lowering herb. The Jamu Saintification development program has been resulted a cholesterol-lowering herb containing of 7 plants. Research on the safety of Jamu (herbal medicine) formula is important to guarantee its use in community.
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